God be with you, general wishes of well being be upon you.
'blessup yo' self foo'
di Psyda 28 luglio 2008

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Top Definition
A greeting of spiritual affirmation between friends - can be used in form of "Hello" or "Goodbye".
"Bless up, brother"
"hey hey, what's going on?"

or

"See you tomorrow, mate"
"Bless up"
di VBR213 10 ottobre 2009

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DJ Khaled a spiritual leader uses this term to indicate his thankfulness to god. It can be used as greetings, after hearing good or bad news. The meaning is not quite clear but it's usage is. Bless up.
Random Dude:Yo! Star wars just came out :D
Major DJ Khaled Fan: Bless Up
di Lord Vignesh 16 aprile 2016

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A term used by celebrity DJ Khaled in order to show reverence to God, or give gratitude to what he has given to you in an opportunity. Also used after hearing something nice, greeting friends, or randomly interjecting statements.
Random Kid: I got an A on the final
DJ Khaled Follower: Bless Up, LIOOON.
di Lord Vignesh 21 aprile 2016

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My tribe uses it as we leave each other to bless and protect each until we meet again.
Awright ma, see you later, bless up.
di aminadaze 02 settembre 2016

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A retard's way of saying "God Bless you." because their brain has a lower processing power than a potato.
Man 1: Hey, how's it going?
Man 2: Bless Up! Heh, YOLO man!
di D33tly 14 aprile 2016

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