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1.
A slang phrase referring to nausea of such extreme intensity that the physical act of vomiting "feels" comparable to expelling the contents of your viscera or gray matter (brain).
If you drink too much alcohol, you'll be "puking your brains out" in front of everyone.
di David in California 23 ottobre 2006
6 2

Words related to puking your brains out:

nausea puke puking sick vomiting